Pig skin as test substrate for evaluating topical antimicrobial activity
نویسندگان
چکیده
منابع مشابه
Antimicrobial activity of topical skin pharmaceuticals - an in vitro study.
The aim of this study was to investigate the antimicrobial activity of currently available topical skin pharmaceuticals against Candida albicans, Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus pyogenes. The agar dilution assay was used to determine the minimal inhibitory concentration for cream formulations and their active substances. Corticosteroid formu...
متن کاملSelection of topical antimicrobial agents for cultured skin for burns by combined assessment of cellular cytotoxicity and antimicrobial activity.
Cultured epidermal skin has become an adjunctive therapy for treatment of major burn injuries, but its effectiveness is greatly limited due to destruction by microbial contamination. To evaluate candidate drugs for use with cultured skin, a combined cytotoxicity-antimicrobial assay system was developed for determination of toxicity to cultured human keratinocytes and fibroblasts, and to common ...
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Eight commercial topical anaesthetic preparations were tested for their ability to inhibit microbial growth in vitro by incubating serial dilutions with each of 4 micro-organisms. In addition corneas of mice were infected with Staphylococcus aureus, and the effect of the anaesthetics on isolation rates of bacteria was investigated. The preparations were shown to have a wide range of antimicrobi...
متن کاملSelected Antimicrobial Activity of Topical Ophthalmic Anesthetics
PURPOSE Endophthalmitis is a rare complication of intravitreal injection (IVI). It is recommended that povidone-iodine be the last agent applied before IVI. Patients have reported povidone-iodine application to be the most bothersome part of IVIs. Topical anesthetics have been demonstrated to have antibacterial effects. This study compared the minimum inhibitory concentration (MIC) of topical a...
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There is an urgent need for new antibiotics and alternative strategies to combat multidrug-resistant bacterial pathogens, which are a growing clinical issue. Repurposing existing approved drugs with known pharmacology and toxicology is an alternative strategy to accelerate antimicrobial research and development. In this study, we show that celecoxib, a marketed inhibitor of cyclooxygenase-2, ex...
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ژورنال
عنوان ژورنال: Journal of Clinical Microbiology
سال: 1986
ISSN: 0095-1137,1098-660X
DOI: 10.1128/jcm.24.3.343-348.1986